ea0041gp93 | Diabetes (2) | ECE2016
Penna-Martinez Marissa
, Hess Helen
, Doring Claudia
, Nejatian Nojan
, Bogdanou Dimitra
, Shoghi Firouzeh
, Hansmann Martin-Leo
, Badenhoop Klaus
Dysregulated T helper cells and vitamin D (VD) deficiency are important factors in the pathogenesis of Type 1 diabetes mellitus (T1D). Therefore, we investigated the immune effects of high dose VD-treatment on gene expression (GE) pattern in T helper cells (Th) before and after VD-therapy in patients with T1D.Methods: Seven T1D patients with 25(OH)D3 levels below 20 ng/ml received 3 months 4000 IU/d Vigantol oil. The 25(OH)D3 plasma...